October 17, 2022 | Page 5 of 5 | Chiral phosphine ligands

Cao, Simin’s team published research in Journal of Physical Chemistry B in 2020-02-06 | 606-68-8

Journal of Physical Chemistry B published new progress about Fluorescence. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt.

Cao, Simin; Li, Haoyang; Liu, Yangyi; Zhang, Mengjie; Wang, Mengyu; Zhou, Zhongneng; Chen, Jinquan; Zhang, Sanjun; Xu, Jianhua; Knutson, Jay R. published the artcile< Femtosecond Fluorescence Spectra of NADH in Solution: Ultrafast Solvation Dynamics>, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt, the main research area is femtosecond fluorescence spectra NADH Solution ultrafast solvation dynamics.

The ultrafast solvation dynamics of reduced NAD (NADH) free in solution has been investigated, using both a femtosecond upconversion spectrophotofluorometer and a picosecond time-correlated single-photon counting (TCSPC) apparatus The familiar time constant of solvent relaxation originating in “”bulk water”” was found to be ∼1.4 ps, revealing ultrafast solvent reorientation upon excitation. We also found a slower spectral relaxation process with an apparent time of 27 ps, suggesting there could either be dissociable “”biol. water”” hydration sites on the surface of NADH or internal dielec. rearrangements of the flexible solvated mol. on that timescale. In contrast, the femtosecond fluorescence anisotropy measurement revealed that rotational diffusion happened on two different timescales (3.6 ps (local) and 141 ps (tumbling)); thus, any dielec. rearrangement scenario for the 27 ps relaxation must occur without significant chromophore oscillator rotation. The coexistence of quasi-static self quenching (QSSQ) with the slower relaxation is also discussed.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Carrasco, Begona’s team published research in Frontiers in Molecular Biosciences in 2022 | 606-68-8

Frontiers in Molecular Biosciences published new progress about Bacillus subtilis. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Electric Literature of 606-68-8.

Carrasco, Begona; Moreno-del Alamo, Maria; Torres, Ruben; Alonso, Juan Carlos published the artcile< PcrA dissociates RecA filaments and the SsbA and RecO mediators counterbalance such activity>, Electric Literature of 606-68-8, the main research area is PcrA RecA filaments SsbA RecO mediator counterbalance activity; ATPase; RecA; RecO; SsbA; UvrD; strand exchange.

PcrA depletion is lethal in wild-type Bacillus subtilis cells. The PcrA DNA helicase contributes to unwinding RNA from the template strand, backtracking the RNA polymerase, rescuing replication-transcription conflicts, and disassembling RecA from single-stranded DNA (ssDNA) by poorly understood mechanisms. We show that, in the presence of RecA, circa one PcrA/plasmid-size circular ssDNA (cssDNA) mol. hydrolyzes ATP at a rate similar to that on the isolated cssDNA. PcrA K37A, which poorly hydrolyzes ATP, fails to displace RecA from cssDNA. SsbA inhibits and blocks the ATPase activities of PcrA and RecA, resp. RecO partially antagonizes and counteracts the neg. effect of SsbA on PcrA- and RecA-mediated ATP hydrolysis, resp. Conversely, multiple PcrA mols. are required to inhibit RecA·ATP-mediated DNA strand exchange (DSE). RecO and SsbA poorly antagonize the PcrA inhibitory effect on RecA.ATP-mediated DSE. An iterative translocating PcrA monomer strips RecA from cssDNA to prevent unnecessary recombination with the mediators SsbA and RecO balancing such activity; and a PcrA cluster that disrupts DNA transactions, as RecA-mediated DSE.

Tanaka, Rie’s team published research in Journal of the American Chemical Society in 2010-02-03 | 139139-86-9

Journal of the American Chemical Society published new progress about Alkynals Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Related Products of 139139-86-9.

Tanaka, Rie; Noguchi, Keiichi; Tanaka, Ken published the artcile< Rhodium-catalyzed asymmetric reductive cyclization of heteroatom-linked 5-alkynals with heteroatom-substituted acetaldehydes>, Related Products of 139139-86-9, the main research area is heteroatom alkynal acetaldehyde rhodium catalyst asym reductive cyclization.

We have established that a cationic rhodium(I)/H8-BINAP complex catalyzes the asym. reductive cyclization of heteroatom-linked 5-alkynals with heteroatom-substituted acetaldehydes in good yields with outstanding enantioselectivity.

Suda, Takeshi’s team published research in Angewandte Chemie, International Edition in 2011 | 139139-86-9

Angewandte Chemie, International Edition published new progress about Alkadiynes Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Product Details of C44H40P2.

Suda, Takeshi; Noguchi, Keiichi; Tanaka, Ken published the artcile< Rhodium-Catalyzed Asymmetric Formal Olefination or Cycloaddition: 1,3-Dicarbonyl Compounds Reacting with 1,6-Diynes or 1,6-Enynes>, Product Details of C44H40P2, the main research area is dicarbonyl stereoselective olefination diyne enyne rhodium BINAP segphos catalyst.

The Rh(I)/(R)-H8-BINAP complex was used as the catalyst in the asym. intermol. olefination of enolizable 1,3-dicarbonyl compounds with 1,6-diynes by [2+2+2]cycloaddition followed by electrocyclic ring opening. The same reaction was also accomplished with 1,6-enynes by using Rh(I)/S-segphos as catalyst.

Tanaka, Ken’s team published research in Angewandte Chemie, International Edition in 2009 | 139139-86-9

Angewandte Chemie, International Edition published new progress about Alkadiynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, COA of Formula: C44H40P2.

Tanaka, Ken; Fukawa, Naohiro; Suda, Takeshi; Noguchi, Keiichi published the artcile< One-Step Construction of Five Successive Rings by Rhodium-Catalyzed Intermolecular Double [2+2+2] Cycloaddition: Enantioenriched [9]Helicene-Like Molecules>, COA of Formula: C44H40P2, the main research area is tetrayne diyne intermol cycloaddition rhodium catalyst; helicene asym preparation crystal mol structure.

The synthesis of [9]helicene-like mols. by rhodium-catalyzed intermol. double [2+2+2] cycloadditions is presented. Crystal structure and photophys. data for the compounds are also determined

Zhang, Xiaoyong’s team published research in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1994-08-21 | 139139-86-9

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Crystal structure. 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Safety of (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Zhang, Xiaoyong; Mashima, Kazushi; Koyano, Kinko; Sayo, Noboru; Kumobayashi, Hidenori; Akutagawa, Susumu; Takaya, Hidemasa published the artcile< Synthesis of partially hydrogenated 2,2'-bis(diphenylphosphenyl)-1,1'-binaphthyl (BINAP) ligands and their application to catalytic asymmetric hydrogenation>, Safety of (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is bisphosphine chiral partially hydrogenated synthesis ligand; ruthenium catalyst hydrogenation chiral phosphine ligand; asym hydrogenation ruthenium catalyst chiral phosphine; crystal structure chiral diphosphine ruthenium cation; mol structure chiral diphosphine ruthenium cation.

Three pairs of new axially dissym. bisphosphine ligands, (R)-(-)- and (S)-(+)-2,2′-bis(dicyclohexylphosphinyl)-1,1′-binaphthyl [ I, R = C6H11], (R)-(+)- and (S)-(-)-2,2′-bis(diphenylphosphinyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl [II, R = Ph], and (R)-(-)- and (S)-(+)-2,2′-bis(dicyclohexylphosphinyl)-5,5′,6,6,7,7′,8,8′-octahydro-1,1′-binaphthyl [II, R = C6H11], have been synthesized. The absolute configurations of the isomers I were determined by single-crystal x-ray diffraction of the linear 1:1 polymeric complex of (S)-(+)-2,2′-bis(dicyclohexylphosphinoyl)-1,1′-binaphthyl [III] and (2R,3R)-(-)-di-O-benzoyltartaric acid [(-)-DBT], and those of the isomers II were established on the basis of CD spectra of the phosphanes and their bisoxides. X-ray crystallog. studies of two cationic Rh1 complexes, [Rh{(S)-Cy-binap}(COD)]ClO4 [(S)-IV] and [Rh{(S)-H8-binap}(COD)]ClO4[(S)-V], revealed that complex (S)-IV possesses a disym. structure, while complex (S)-V has a pseudo-C2-symmetry and shows a significantly large dihedral angle between the two Ph rings [80.3(4)°]. The potentially of ligand II for asym. catalysis was demonstrated in RuII-catalyzed stereoselective hydrogenations of Me 2-(benzamidomethyl)-3-oxobutanoate, (in up to 92% d.e. and 99% e.e.) and geraniol (in 98% optical purity).

Trost, Barry M’s team published research in Angewandte Chemie, International Edition in 2011 | 152140-65-3

Angewandte Chemie, International Edition published new progress about Allylic alkylation (decarboxylative, stereoselective). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, COA of Formula: C54H42N2O2P2.

Trost, Barry M.; Schaeffner, Benjamin; Osipov, Maksim; Wilton, Donna A. A. published the artcile< Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of β-ketoesters: An Unusual Counterion Effect>, COA of Formula: C54H42N2O2P2, the main research area is stereoselective decarboxylative allylic alkylation keto ester palladium catalyst.

The palladium-catalyzed decarboxylative asym. allylic alkylation of β-keto esters is reported. This reaction was applied to the synthesis of (-)-ranirestat. It was expanded to β-keto esters by using allyl chloroformate to form allyl enol carbonates in situ. Two sets of reaction conditions were developed to fine-tune the enantioselectivity.