Luo, Hongwen; Yang, Zheng; Lin, Weilong; Zheng, Yangguangyan; Ma, Shengming published the artcile< A catalytic highly enantioselective allene approach to oxazolines>, Electric Literature of 152140-65-3, the main research area is oxazoline preparation enantioselective; allene aryl iodide coupling cyclization palladium catalyst.
Here, a highly enantioselective palladium-catalyzed coupling-cyclization of readily available N-(buta-2,3-dienyl)amides with aryl or 1-alkenyl iodides has been developed for the asym. construction of oxazoline derivatives I (R1 = Ph, 2-thienyl, 4-FC6H4, etc.; R2 = Ph, 3-MeC6H4, 4-FC6H4, etc.). Many synthetically useful functional groups are tolerated in this reaction. The absolute configuration of the chiral center in the products has been established by X-ray diffraction study. A model for prediction of the absolute configuration of the chiral center in the products from this cyclic enantioselective nucleophilic allylation has been proposed. The synthetic potentials based on the unique structure of the products formed have also been demonstrated.
Chemical Science published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Electric Literature of 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate