《Novel N,N,P-Tridentate Ligands for the Highly Enantioselective Copper-Catalyzed 1,4-Addition of Dialkylzincs to Enones》 was written by Kawamura, Kenjiro; Fukuzawa, Hitomi; Hayashi, Masahiko. Safety of (S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine And the article was included in Organic Letters on August 21 ,2008. The article conveys some information:
Use of 0.25 mol % of the N,N,P-tridentate ligands (S)-QuCH:NCHRCH2PPh2 (Qu = 2-quinolyl) and 0.1 mol % of Cu(OTf)2 enabled the enantioselective 1,4-addition of dialkylzincs to cyclic enones to produce 1,4-adducts in up to 99% ee.(S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas: 286454-86-2Safety of (S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine) was used in this study.
(S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas:286454-86-2) is one of aminophosphine type ligands. An increased interest in aminophosphine type ligands used for asymmetric synthesis has been witnessed.Safety of (S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine This growth in popularity of aminophosphine ligands in asymmetric synthesis is in part due to the growing number of convenient synthetic pathways leading to useful ligand sets.
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis