Quality Control of (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine]On May 7, 2021 ,《Copper-Catalyzed Asymmetric Reductions of Aryl/Heteroaryl Ketones under Mild Aqueous Micellar Conditions》 appeared in Organic Letters. The author of the article were Fialho, David M.; Etemadi-Davan, Elham; Langner, Olivia C.; Takale, Balaram S.; Gadakh, Amol; Sambasivam, Ganesh; Lipshutz, Bruce H.. The article conveys some information:
Enantioselective syntheses of nonracemic secondary alcs. have been achieved in an aqueous micellar medium via copper-catalyzed (Cu(OAc)2.H2O/(R)-3,4,5-MeO-MeO-BIPHEP) reduction of aryl/heteroaryl ketones. This methodol. serves as a green protocol to access enantio-enriched alcs. under mild conditions (0-22°C) using a base metal catalyst, together with an inexpensive, innocuous, and convenient stoichiometric hydride source (PMHS). The secondary alc. products are formed in good to excellent yields with ee values greater than 90%. In the experiment, the researchers used (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine](cas: 256390-47-3Quality Control of (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine])
(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine](cas: 256390-47-3) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds. Quality Control of (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine]
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis