Ebisu, Yasuhiro; Kawamura, Kenjiro; Hayashi, Masahiko published an article in Tetrahedron: Asymmetry. The title of the article was 《Enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones using a novel N,N,P-Cu(II) complex》.Application of 286454-86-2 The author mentioned the following in the article:
Enantioselective copper-catalyzed 1,4-additions of dialkylzincs R2Zn (R = Et, Me) to enones I [X = (CH2)n, n = 0-2] and II (R1 = H, R2 = H, Me; R1 = MeO, NO2, F, R2 = H) were carried out in the presence of 1 mol % of Cu(OTf)2 and 2.5 mol % of an N,N,P-ligand possessing a tert-Bu group at the adjacent position of the nitrogen of pyridine to afford the corresponding 1,4-adducts III and IV, resp., in up to 98% ee. The results came from multiple reactions, including the reaction of (S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas: 286454-86-2Application of 286454-86-2)
(S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas:286454-86-2) is one of aminophosphine type ligands. An increased interest in aminophosphine type ligands used for asymmetric synthesis has been witnessed.Application of 286454-86-2 This growth in popularity of aminophosphine ligands in asymmetric synthesis is in part due to the growing number of convenient synthetic pathways leading to useful ligand sets.
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis