Arai, Takayoshi; Sato, Katsuya; Nakamura, Ayu; Makino, Hiroki; Masu, Hyuma published their research in Scientific Reports on December 31 ,2018. The article was titled 《Dinuclear PhosphoiminoBINOL-Pd Container for Malononitrile: Catalytic Asymmetric Double Mannich Reaction for Chiral 1,3-Diamine Synthesis》.Product Details of 286454-86-2 The article contains the following contents:
A phosphoiminoBINOL ligand was designed to form a dinuclear metal complex that could hold a malononitrile mol. The dinuclear bis(phosphoimino)binaphthoxy-Pd2(OAc)2 complex catalyzed a double Mannich reaction of N-Boc-imines with malononitrile to give chiral 1,3-diamines I (R = Ph, 2-MeC6H4, 2-NO2C6H4, etc.) with high enantioselectivity. The rational asym. catalyst, which smoothly introduces the first coupling product to the second coupling reaction while avoiding the reverse reaction, facilitates the over-reaction into a productive reaction process. After reading the article, we found that the author used (S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas: 286454-86-2Product Details of 286454-86-2)
(S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas:286454-86-2) is one of aminophosphine type ligands. An increased interest in aminophosphine type ligands used for asymmetric synthesis has been witnessed.Product Details of 286454-86-2 This growth in popularity of aminophosphine ligands in asymmetric synthesis is in part due to the growing number of convenient synthetic pathways leading to useful ligand sets.
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis