Webster, Robert; Boyer, Alistair; Fleming, Matthew J.; Lautens, Mark published the artcile< Practical Asymmetric Synthesis of Bioactive Aminotetralins from a Racemic Precursor Using a Regiodivergent Resolution>, Name: (2S)-1-[(1S)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene, the main research area is oxabicyclic alkene chiral rhodium catalyst amine ring opening; aminotetralin stereoselective preparation regiodivergent resolution; rotigotine stereoselective preparation.
Catalyst-controlled asym. ring opening of racemic oxabicyclic alkene I leads to two readily separable regioisomeric products, both in excellent ee. A cationic Rh catalyst, with added NH4BF4 to modulate reactivity, was required to obtain synthetically useful yields. The utility of each substituted aminotetralin product has been demonstrated by their conversion to the biol. relevant mols. Rotigotine and (S)-8-OH-DPAT in a highly efficient and practical manner.
Organic Letters published new progress about Chiral resolution (regiodivergent). 277306-29-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C32H40FeP2, Name: (2S)-1-[(1S)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate