Wang, Duo-Sheng; Chen, Qing-An; Li, Wei; Yu, Chang-Bin; Zhou, Yong-Gui; Zhang, Xumu published the artcile< Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles Activated by Bronsted Acids>, Formula: C44H40P2, the main research area is indoline asym preparation reaction mechanism; unprotected indole asym hydrogenation palladium catalyst Bronsted acid activator; dynamic kinetic resolution.
The first highly enantioselective hydrogenation of simple indoles was developed with a Bronsted acid as an activator to form the iminium intermediate in situ, which was hydrogenated using Pd(OCOCF3)2/(R)-H8-BINAP catalyst system with up to 96% ee. The present method provides an efficient route to enantioenriched 2-substituted, e.g., I and 2,3-disubstituted indolines.
Journal of the American Chemical Society published new progress about Bronsted acids Role: CAT (Catalyst Use), USES (Uses). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Formula: C44H40P2.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate