Trost, Barry M.; Tang, Weiping published the artcile< Migratory Hydroamination: A Facile Enantioselective Synthesis of Benzomorphans>, Recommanded Product: N,N’-(11R,12R)-(9,10-Dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)benzamide], the main research area is benzomorphan alkaloid asym preparation; diastereoselective cycloisomerization benzomorphan alkaloid asym preparation; migratory hydroamination benzomorphan alkaloid asym preparation; asym allylic alkylation benzomorphan alkaloid asym preparation.
A highly efficient, general strategy for the enantioselective synthesis of benzomorphans (45-46% overall yield from com. available material) is described. The new synthesis demonstrates the effectiveness of an unprecedented diastereoselective cycloisomerization via migratory hydroamination and the power of palladium-catalyzed asym. allylic alkylation (AAA) of simple ketone enolates in the context of complex synthesis. The strategy outlined here for the enantioselective synthesis of three contiguous stereogenic centers and the novel cycloisomerization should have many applications in alkaloid synthesis.
Journal of the American Chemical Society published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Recommanded Product: N,N’-(11R,12R)-(9,10-Dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)benzamide].
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate