Tabuchi, Sho; Hirano, Koji; Miura, Masahiro published the artcile< Palladium-Catalyzed Asymmetric Benzylic Alkylation of Active Methylene Compounds with α-Naphthylbenzyl Carbonates and Pivalates>, Reference of 139139-93-8, the main research area is palladium catalyst asym benzylic alkylation active methylene compound; asymmetric catalysis; kinetic resolution; ligand effects; palladium; synthetic methods.
A Pd/(R)-H8-BINAP-catalyzed asym. benzylic alkylation of active methylene compounds has been developed. The reaction proceeds without the use of an external base, and the starting racemic diarylmethyl carbonates are converted into the optically active coupling products which contain the benzylic chiral stereocenter by a dynamic kinetic asym. transformation (DYKAT). Addnl., with suitable carbonates bases, the same palladium catalysis allows the corresponding pivalates to be adopted in the same DYKAT process.
Angewandte Chemie, International Edition published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Reference of 139139-93-8.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate