Seo, Kyeongdeok; Jang, Seok Hyeon; Rhee, Young Ho published the artcile< Sequential Metal Catalysis towards 7-Oxostaurosporine and Its Non-Natural Septanose Analogue>, Related Products of 152140-65-3, the main research area is palladium catalyzed oxidative cyclization bicyclic aminoglycoside septanose oxostaurosporine preparation; septanose oxostaurosporine metal catalysis indolocarbazole alkoxyallene chemoselective addition synthon; Asymmetric synthesis; De novo synthesis; Indolocarbazole; Olefin migration; Total synthesis.
We report sequential metal catalysis towards indolocarbazole glycosides. The signature event is highlighted by (i) Pd0-catalyzed addition of indolocarbazole to alkoxyallene combined with ring-closing-metathesis; (ii) Ru-catalyzed chemoselective olefin migration; (iii) PdII-catalyzed oxidative cyclization to build the bicyclic core structure of the target compounds This approach gave access to both natural pyranose- and non-natural septanose glycosides. A short formal synthesis of 7-oxostaurosporine was achieved via this strategy.
Angewandte Chemie, International Edition published new progress about Aminoglycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Related Products of 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate