Day: October 14, 2022

Wang, Duo-Sheng; Chen, Qing-An; Li, Wei; Yu, Chang-Bin; Zhou, Yong-Gui; Zhang, Xumu published the artcile< Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles Activated by Bronsted Acids>, Formula: C44H40P2, the main research area is indoline asym preparation reaction mechanism; unprotected indole asym hydrogenation palladium catalyst Bronsted acid activator; dynamic kinetic resolution.

The first highly enantioselective hydrogenation of simple indoles was developed with a Bronsted acid as an activator to form the iminium intermediate in situ, which was hydrogenated using Pd(OCOCF3)2/(R)-H8-BINAP catalyst system with up to 96% ee. The present method provides an efficient route to enantioenriched 2-substituted, e.g., I and 2,3-disubstituted indolines.

Journal of the American Chemical Society published new progress about Bronsted acids Role: CAT (Catalyst Use), USES (Uses). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Formula: C44H40P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Konrad, Tina M.; Fuentes, Jose A.; Slawin, Alexandra M. Z.; Clarke, Matthew L. published the artcile< Highly Enantioselective Hydroxycarbonylation and Alkoxycarbonylation of Alkenes using Dipalladium Complexes as Precatalysts>, Application In Synthesis of 325168-88-5, the main research area is paracyclophane diphosphine palladium complex preparation enantioselective hydroxycarbonylation alkoxycarbonylation catalyst; styrene norbornene asym hydroxycarbonylation alkoxycarbonylation palladium phanephos catalyst.

A highly stereoselective process for hydroxycarbonylation and alkoxycarbonylation of alkenes [styrene, 4-(tert-butyl)styrene, norbornene] using (R)-PHANEPHOS- and (R)- or (S)-Xylyl-PHANEPHOS-bridged dipalladium complexes as precatalysts has been developed. The process operates below 100 °C, uses less than 1 equivalent of an acid promoter and delivers the product with up to 95% ee.

Angewandte Chemie, International Edition published new progress about Aliphatic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 325168-88-5 belongs to class chiral-phosphine-ligands, and the molecular formula is C48H50P2, Application In Synthesis of 325168-88-5.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Shintani, Ryo; Takano, Ryo; Nozaki, Kyoko published the artcile< Rhodium-catalyzed asymmetric synthesis of silicon-stereogenic silicon-bridged arylpyridinones>, Category: chiral-phosphine-ligands, the main research area is rhodium catalyzed asym synthesis silicon stereogenic bridged arylpyridinone; cycloaddition silyl prochiral triyne isocyanate rhodium catalyzed; alkynyl benzopyridosilacyclopentene preparation crystal mol structure.

A rhodium-catalyzed regio- and enantioselective synthesis of silicon-stereogenic silicon-bridged arylpyridinones has been developed through [2 + 2 + 2] cycloaddition of silicon-containing prochiral triynes with isocyanates. High yields and enantioselectivities have been achieved by employing an axially chiral monophosphine ligand, and this process could be applied to catalytic asym. synthesis of silicon-stereogenic chiral polymers for the first time. The reaction mechanism of the present catalysis has also been exptl. investigated to establish a reasonable catalytic cycle, advancing the mechanistic understanding of the rhodium-catalyzed pyridinone synthesis by [2 + 2 + 2] cycloaddition reactions.

Chemical Science published new progress about [2+2+2] Cycloaddition reaction. 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Category: chiral-phosphine-ligands.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Valli, Matteo; Bruno, Paolo; Sbarbada, Davide; Porta, Alessio; Vidari, Giovanni; Zanoni, Giuseppe published the artcile< Stereodivergent Strategy for Neurofuran Synthesis via Palladium-Catalyzed Asymmetric Allylic Cyclization: Total Synthesis of 7-epi-ST-Δ8-10-Neurofuran>, Computed Properties of 152140-65-3, the main research area is neurofuran synthesis asym allylic cyclization.

An enantioselective stereodivergent approach to two key neurofuran precursors, belonging to the AC and ST classes, has been developed starting from a single achiral precursor. The absolute configuration of the THF cores was secured by a Pd-catalyzed asym. allylic alkylation. From the ST precursor, 7-epi-ST-Δ8-10-neurofuran (I) was prepared

Journal of Organic Chemistry published new progress about Allylic alkylation, stereoselective. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Computed Properties of 152140-65-3.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Shibata, Takanori; Fujimoto, Masako; Hirashima, Hiroyuki; Chiba, Tatsuya; Endo, Kohei published the artcile< Facile synthesis of cyclic polyphenylenes by consecutive inter- and intramolecular cycloadditions of ortho-, meta-, and para-phenylene-tethered triynes>, Formula: C44H40P2, the main research area is cyclic polyphenylene synthesis phenylene tethered triyne.

Consecutive inter- and intramol. [2 + 2 + 2] cycloadditions of various phenylene-tethered triynes were comprehensively studied by using chiral rhodium catalysts. Ortho-Phenylene-tethered triynes gave chiral o,o,o,o-tetraphenylenes in high-to-excellent enantiomeric excess as dimers. Meta-Phenylene-tethered triynes gave chiral o,m,o,m-tetraphenylenes in moderate enantiomeric excess as dimers along with hexaphenylenes as trimers. This is the first synthesis of cis-o,m,o,m-tetraphenylenes; one structure was ascertained by X-ray crystal structure anal. Para-Phenylene-tethered triynes gave o,p,o,p,o,p-hexaphenylenes as trimers along with the formation of o,p,o,p,o,p,o,p-octaphenylenes as tetramers.

Synthesis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Formula: C44H40P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Michon, Christophe; Bethegnies, Aurelien; Capet, Frederic; Roussel, Pascal; de Filippis, Arnault; Gomez-Pardo, Domingo; Cossy, Janine; Agbossou-Niedercorn, Francine published the artcile< Catalytic Asymmetric Allylic Alkylation of 3-Arylated Piperidin-2-ones>, HPLC of Formula: 152140-65-3, the main research area is preparation chiral allyl pyrimidine derivative asym alkylation catalysis.

The preparation of optically active lactams from 3-aryl-2-piperidinone is reported. The quaternary carbon stereo-centers were formed using palladium-catalyzed asym. allylic alkylation reactions. The resulting enantio-enriched compounds are useful intermediates for the synthesis and development of neurokinin antagonists.

European Journal of Organic Chemistry published new progress about Alkylation, stereoselective (allylic). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, HPLC of Formula: 152140-65-3.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Shintani, Ryo; Maciver, Eleanor E.; Tamakuni, Fumiko; Hayashi, Tamio published the artcile< Rhodium-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic Dibenzooxasilines via Enantioselective Transmetalation>, Recommanded Product: (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is rhodium catalyzed asym synthesis dibenzooxasiline enantioselective transmetalation; diarylsilylbiphenylol preparation rhodium diphosphine catalyzed cyclization enantioselectivity; crystal mol structure dibenzooxasiline.

A rhodium-catalyzed asym. synthesis of silicon-stereogenic dibenzooxasilines has been developed. High enantioselectivities have been achieved by employing (S,S)-Me-Duphos as the ligand through “”enantioselective transmetalation””.

Journal of the American Chemical Society published new progress about Crystal structure. 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Recommanded Product: (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Kita, Yusuke; Kavthe, Rahul D.; Oda, Hiroaki; Mashima, Kazushi published the artcile< Asymmetric Allylic Alkylation of β-Ketoesters with Allylic Alcohols by Nickel/Diphosphine Catalyst>, Safety of (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is enantioselective allylic alkylation nickel diphosphine catalyst; alkylation beta ketoester allylic alc; alkylation; allylic compounds; asymmetric catalysis; enantioselectivity; nickel.

Asym. allylic alkylation of β-ketoesters with allylic alcs. catalyzed by [Ni(cod)2]/(S)-H8-BINAP was found to be a superior synthetic protocol for constructing quaternary chiral centers at the α-position of β-ketoesters. The reaction proceeded in high yield and with high enantioselectivity using various β-ketoesters and allylic alcs., without any addnl. activators. The versatility of this methodol. for accessing useful and enantioenriched products was demonstrated.

Angewandte Chemie, International Edition published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Safety of (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Oonishi, Yoshihiro; Masusaki, Shuichi; Sakamoto, Shunki; Sato, Yoshihiro published the artcile< Rhodium(I)-Catalyzed Enantioselective Cyclization of Enynes by Intramolecular Cleavage of the Rh-C Bond by a Tethered Hydroxy Group>, Safety of (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is acyl heterocyclic compound enantioselective preparation; enynol preparation enantioselective cyclization rhodium catalyst; cyclization; enantioselectivity; enyne; rhodium; σ-bond metathesis.

Rhodium(I)-catalyzed enantioselective intramol. cyclization of enynes having a hydroxy group in the tether was investigated, and various cyclic compounds possessing a chiral quaternary carbon center were obtained in high yields with high ees. In this cyclization, a Rh-C(sp2) bond in the rhodacyclopentene intermediate, which was formed by enantioselective oxidative cycloaddition of enynes to a chiral rhodium(I) complex, was intramolecularly cleaved by σ-bond metathesis of a tethered O-H bond in the substrate. Furthermore, it was found that the cyclic compounds were obtained with high ees even when the starting materials having a racemic secondary alc. moiety were used in this reaction.

Angewandte Chemie, International Edition published new progress about Alcohols, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Safety of (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Oonishi, Yoshihiro; Hato, Yoshio; Sato, Yoshihiro published the artcile< Rhodium(I)-Catalyzed Diastereoselective Cycloisomerization of Enynes with Tethered (S)-2-Methyl-2-propanesulfinyl Imine>, Application of C44H40P2, the main research area is enyne tethered sulfinyl imine rhodium catalyst cycloisomerization; cyclic diene enantioselective diastereoselective preparation dienophile Diels Alder reaction; spiroamide diastereoselective enantioselective preparation.

The rhodium(I)-catalyzed cycloisomerization of enynes with tethered (S)-2-methyl-2-propanesulfinyl imine afforded 5- or 6-membered cyclic compounds containing exocyclic 1,3-diene moieties in a stereoselective manner. The reaction proceeded through β-hydride elimination of a 7-membered azarhodacycle intermediate, which was generated from three unsaturated bonds (i.e., alkene, alkyne, and C-N bonds) and an Rh(I) complex. The resultant cyclic compounds could be reacted with various dienophiles to afford spiroamides as single isomers through the Diels-Alder reaction.

Advanced Synthesis & Catalysis published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Application of C44H40P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate