Ludwig, Janet C.; Misiorowski, Ronald L.; Chvapil, Milos; Seymour, Michael D. published the artcile< Interaction of zinc ions with electron carrying coenzymes NADPH and NADH>, Related Products of 606-68-8, the main research area is zinc NADH drug metabolism inhibition.
The substrate for the drug-oxidizing system, NADPH, binds to Zn2+, but NADH does not. Equilibrium gel filtration and acid titrations of Zn2+ and NADPH tetrasodium salt indicated a molar ratio of metal to nucleotide of 2:1 and a formation constant of 106.75. 31P-NMR, UV, and fluorescence spectra of the complex indicated the possible binding sites of Zn2+ to NADPH. Since Zn2+ is known to inhibit the metabolism of drugs by mixed function oxidases in liver microsomes, the formation of the Zn2+-NADPH complex suggests the mechanism by which Zn2+ may inhibit the drug-oxidizing system.
Chemico-Biological Interactions published new progress about Drug-metabolizing enzymes Role: BIOL (Biological Study). 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Related Products of 606-68-8.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate