Kita, Yusuke; Kavthe, Rahul D.; Oda, Hiroaki; Mashima, Kazushi published the artcile< Asymmetric Allylic Alkylation of β-Ketoesters with Allylic Alcohols by Nickel/Diphosphine Catalyst>, Safety of (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is enantioselective allylic alkylation nickel diphosphine catalyst; alkylation beta ketoester allylic alc; alkylation; allylic compounds; asymmetric catalysis; enantioselectivity; nickel.
Asym. allylic alkylation of β-ketoesters with allylic alcs. catalyzed by [Ni(cod)2]/(S)-H8-BINAP was found to be a superior synthetic protocol for constructing quaternary chiral centers at the α-position of β-ketoesters. The reaction proceeded in high yield and with high enantioselectivity using various β-ketoesters and allylic alcs., without any addnl. activators. The versatility of this methodol. for accessing useful and enantioenriched products was demonstrated.
Angewandte Chemie, International Edition published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Safety of (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate