Holzheimer, Mira; Sinninghe Damste, Jaap S.; Schouten, Stefan; Havenith, Remco W. A.; Cunha, Ana V.; Minnaard, Adriaan J. published the artcile< Total Synthesis of the Alleged Structure of Crenarchaeol Enables Structure Revision>, Product Details of C54H42N2O2P2, the main research area is crenarchaeol total synthesis structure revision; macrocyclization total synthesis crenarchaeol; ring closing metathesis total synthesis crenarchaeol; archaea; crenarchaeol; structure revision; tetraether lipid; total synthesis.
Crenarchaeol is a glycerol dialkyl glycerol tetraether lipid produced exclusively in Archaea of the phylum Thaumarchaeota. This membrane-spanning lipid is undoubtedly the structurally most sophisticated of all known archaeal lipids and an iconic mol. in organic geochem. The 66-membered macrocycle possesses a unique chem. structure featuring 22 mostly remote stereocenters, and a cyclohexane ring connected by a single bond to a cyclopentane ring. Herein, we report the first total synthesis of the proposed structure of crenarchaeol. Comparison with natural crenarchaeol allowed us to propose a revised structure of crenarchaeol, wherein one of the 22 stereocenters is inverted.
Angewandte Chemie, International Edition published new progress about Absolute configuration. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Product Details of C54H42N2O2P2.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate