Das, Mrinal K.; Kumar, Nivesh; Bisai, Alakesh published the artcile< Catalytic Asymmetric Total Syntheses of Naturally Occurring Amarylidaceae Alkaloids, (-)-Crinine, (-)-epi-Crinine, (-)-Oxocrinine, (+)-epi-Elwesine, (+)-Vittatine, and (+)-epi-Vittatine>, Quality Control of 152140-65-3, the main research area is asym catalytic total synthesis Amaryllidaceae alkaloid; crinine catalytic asym total synthesis decarboxylative allylation; epi crinine catalytic asym total synthesis decarboxylative allylation; oxocrinine catalytic asym total synthesis decarboxylative allylation; elwesine epi catalytic asym total synthesis decarboxylative allylation; vittatine catalytic asym total synthesis decarboxylative allylation.
An expeditious approach to catalytic enantioselective total syntheses of crinine-type Amaryllidaceae alkaloids has been accomplished via a Pd-catalyzed enantioselective decarboxylative allylation of allylenol carbonates as a key step (up to 96% ee). Using this strategy, collective total syntheses of Amaryllidaceae alkaloids such as (-)-epi-elwesine I (R = OH, R1 = R2 = H), (-)-crinine I (R = H, R1 = OH, R22 = bond), (-)-epi-crinine I (R = OH, R1 = H, R22 = bond), (-)-oxocrinine I (RR1 = O, R22 = bond), and (-)-buphanisine I (R = H, R1 = OH, R22 = bond) have been accomplished. Gratifyingly, naturally occurring Amaryllidaceae alkaloids such as (+)-vittatine II (R = OH, R1 = H, R22 = bond), (+)-epi-vittatine II (R = H, R1 = OH, R22 = bond), and (+)-epi-elwesine II (R = R2 = H, R1 = OH) have also been achieved by switching the antipode of the ligand used in the catalytic enantioselective step.
Organic Letters published new progress about Allylation catalysts, stereoselective (decarboxylative). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Quality Control of 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate