In 2018,Bora, Pranjal P.; Sun, Gui-Jun; Zheng, Wei-Feng; Kang, Qiang published 《Rh/Lewis Acid Catalyzed Regio-, Diastereo- and Enantioselective Addition of 2-Acyl Imidazoles with Allenes》.Chinese Journal of Chemistry published the findings.Synthetic Route of C38H28O4P2 The information in the text is summarized as follows:
A highly regio-, diastereo- and enantioselective addition of 2-acyl imidazoles or 2-acyl pyridines with allenes promoted by Rh/Lewis acid synergistically catalytic system was described. This atom economic approach led to the formation of the branched allylic alkylated products including acyclic quaternary all-carbon stereogenic centers in good yields with good to excellent diastereo- and enantioselectivities. Kinetic studies revealed that the rate-determining step in this process was the oxidative addition of Rh(I) with C-H bond. The results came from multiple reactions, including the reaction of (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3Synthetic Route of C38H28O4P2)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) may be used for: regio- and stereoselective preparation of axially chiral arylnaphthalene derivatives via rhodium-catalyzed [2+2+2] cycloaddition of diynes with naphthalenepropynoic acid derivatives or diastereo- and enantioselective hydrogenation of α-amino-β-keto ester hydrochlorides catalyzed by an iridium complex.Synthetic Route of C38H28O4P2
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis