Zhang, Jiacheng; Huo, Xiaohong; Xiao, Junzhe; Zhao, Ling; Ma, Shengming; Zhang, Wanbin published their research in Journal of the American Chemical Society in 2021. The article was titled 《Enantio- and Diastereodivergent Construction of 1,3-Nonadjacent Stereocenters Bearing Axial and Central Chirality through Synergistic Pd/Cu Catalysis》.Computed Properties of C38H28O4P2 The article contains the following contents:
Herein, an enantio- and diastereodivergent construction of 1,3-nonadjacent stereocenters bearing allenyl axial and central chirality through synergistic Pd/Cu-catalyzed dynamic kinetic asym. allenylation with racemic allenylic esters was reported. The protocol was suitable for a wide range of substrates including the challenging allenylic esters with less sterically bulky substituents and provided chiral allenylic products I [R = n-Bu, Ph, CMe2OTBS, etc.; Ar = Ph, 2-naphthyl, 2-furyl, etc.; stereo = R or S] bearing 1,3-nonadjacent stereocenters with high levels of enantio- and diastereoselectivities (up to >20:1 dr and >99% ee). Furthermore, several representative transformations involving axial-to-central chirality transfer were conducted, affording useful structural motifs containing nonadjacent stereocenters in a diastereodivergent manner. In the experiment, the researchers used (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3Computed Properties of C38H28O4P2)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) is a chelating ligand used to prepare coordination complex catalysts, such as its use in Pd catalysts for the enantioselective synthesis of spiro- or benzofused hetereocycles with exocyclic olefins via enantioselective intramolecular dearomative Heck reaction of indoles, benzofurans, pyrroles and furans.Computed Properties of C38H28O4P2
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis