Yoshida, Mariko; Nemoto, Tetsuhiro; Zhao, Zengduo; Ishige, Yuta; Hamada, Yasumasa published the artcile< Enantioselective construction of all-carbon quaternary spirocenters through a Pd-catalyzed asymmetric intramolecular ipso-Friedel-Crafts allylic alkylation of phenols>, Name: N,N’-(11R,12R)-(9,10-Dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)benzamide], the main research area is spirocyclohexadienone enantioselective synthesis; phenol Friedel Crafts allylic alkylation chiral ligand Pd catalyst.
A novel catalytic asym. synthetic method for making spirocyclohexadienones e. g., I with an all-carbon quaternary spirocenter was developed based on the Pd-catalyzed intramol. ipso-Friedel-Crafts allylic alkylation of phenols. When 5 mol % of the Pd catalyst and 12 mol % of (-)-9-NapBN (-) were used, the spirocyclic adduct was obtained with up to 93% ee, albeit with low chem. yield. On the other hand, when using 6 mol% of the Trost ligand (R,R), the spirocyclic adducts were obtained in good yields with up to 89% ee (diastereoselectivity = 9.2:1).
Tetrahedron: Asymmetry published new progress about Allylic alkylation. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Name: N,N’-(11R,12R)-(9,10-Dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)benzamide].
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate