Williams, David R.; Shah, Akshay A. published the artcile< Total Synthesis of (+)-Ileabethoxazole via an Iron-Mediated Pauson-Khand [2 + 2 + 1] Carbocyclization>, Recommanded Product: (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is ileabethoxazole total synthesis Pauson Khand carbocyclization iron; Stille cross coupling total synthesis ileabethoxazole; insertion total synthesis ileabethoxazole; asym hydride reduction copper total synthesis ileabethoxazole.
Studies describe the total synthesis of (+)-ileabethoxazole (I) using a Stille cross-coupling reaction of propargylic stannanes with 5-iodo-1,3-oxazoles to produce 1,1-disubstituted allenes. An iron-mediated [2+2+1] carbocyclization yields a novel cyclopentenone II (R = H, Me) for elaboration to I. Site-selective palladium insertion reactions allow for regiocontrolled substitutions of the heterocycle. Asym. copper hydride reductions are examined, and strategies for the formation of the central aromatic ring are discussed.
Journal of the American Chemical Society published new progress about Cyclization (Pauson-Khand [2+2+1]-carbocyclization). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Recommanded Product: (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate