Li, Qiankun’s team published research in Angewandte Chemie, International Edition in 2014 | CAS: 256390-47-3

(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine](cas: 256390-47-3) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds. Formula: C50H56O14P2

The author of 《Palladium-Catalyzed Asymmetric Amination of Allenyl Phosphates: Enantioselective Synthesis of Allenes with an Additional Unsaturated Unit》 were Li, Qiankun; Fu, Chunling; Ma, Shengming. And the article was published in Angewandte Chemie, International Edition in 2014. Formula: C50H56O14P2 The author mentioned the following in the article:

In the presence of a nonracemic bis[bis(trimethoxyphenyl)phosphino]biphenyl and bis(allylpalladium chloride) and using DBU in o-xylene, tosylamides RNHTs (R = H2C:CHCH2, Me2C:CHCH2, H2C:CMeCH2, HCCCH2, n-PrCCCH2, H2C:C:CHCH2, PhCH2, Me; Ts = 4-MeC6H4SO2) underwent regioselective and enantioselective substitution reactions with allenylmethyl phosphates H2C:C:CHCHR1OP(:O)(OEt)2 [R1 = BuCH2CH2, Bu, PhCH2CH2, H2C:CH(CH2)8, Cl(CH2)5, THPO(CH2)5, Me3SiCC(CH2)3, n-Pr; THP = tetrahydropyran-2-yl] to give nonracemic allenylmethylamines such as (S)-H2C:C:CHCHR1NRTs [R = H2C:CHCH2, Me2C:CHCH2, H2C:CMeCH2, HCCCH2, n-PrCCCH2, H2C:C:CHCH2, PhCH2, Me; R1 = BuCH2CH2, Bu, PhCH2CH2, H2C:CH(CH2)8, Cl(CH2)5, HO(CH2)5, Me3SiCC(CH2)3, n-Pr] (I) in 47-90% yields and in 88-94% ee. The structure of a nonracemic cyclopentapyridinone dinitrophenylhydrazone derived from I (R = n-PrCCCH2; R1 = BuCH2CH2) in two steps was determined by X-ray crystallog. In addition to this study using (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine], there are many other studies that have used (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine](cas: 256390-47-3Formula: C50H56O14P2) was used in this study.

(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine](cas: 256390-47-3) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds. Formula: C50H56O14P2

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis