Category: chiral-phosphine-ligandsOn October 4, 2017 ,《Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts》 was published in Journal of the American Chemical Society. The article was written by Garcia-Morales, Cristina; Ranieri, Beatrice; Escofet, Imma; Lopez-Suarez, Laura; Obradors, Carla; Konovalov, Andrey I.; Echavarren, Antonio M.. The article contains the following contents:
The enantioselective intermol. gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes was achieved using non-C2-chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach was applied to the enantioselective total synthesis of rumphellaone A. After reading the article, we found that the author used (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8Category: chiral-phosphine-ligands)
(R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. Category: chiral-phosphine-ligands These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds.
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis