Trost, Barry M.; Brennan, Megan K. published the artcile< Palladium-Catalyzed Regio- and Enantioselective Allylic Alkylation of Bis Allylic Carbonates Derived from Morita-Baylis-Hillman Adducts>, Safety of N,N’-(11R,12R)-(9,10-Dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)benzamide], the main research area is Morita Baylis Hillman adduct regioselective enantioselective allylic alkylation; palladium phosphinonaphthoylaminocyclohexane catalysis regioselective enantioselective allylic alkylation; allylic carbonate regioselective enantioselective allylic alkylation palladium catalysis.
Morita-Baylis-Hillman diene adducts (e.g. (4E)-3-[(ethoxycarbonyl)oxy]-2-methylenehex-4-enoic acid Me ester) were used as substrates in the Pd-catalyzed asym. allylic alkylation reaction with O and C nucleophiles (e.g. p-methoxyphenol) in good regio- and enantioselectivity, e.g. 78 % (88 %ee) (3S,4E)-(+)-3-(4-methoxyphenoxy)-2-methylenehex-4-enoic acid Me ester (>20:1 regioisomers), using Pd2(dba)3, (1S,2S)-1,2-bis[[[2-(diphenylphosphino)naphthalen-1-yl]carbonyl]amino]cyclohexane and tetrabutylammonium triphenyldifluorosilicate as catalyst system in DME at 25°.
Organic Letters published new progress about Allylic alkylation catalysts, stereoselective (regioselective). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Safety of N,N’-(11R,12R)-(9,10-Dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)benzamide].
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate