Trost, Barry M.; Xu, Jiayi published the artcile< Palladium-Catalyzed Asymmetric Allylic α-Alkylation of Acyclic Ketones>, HPLC of Formula: 152140-65-3, the main research area is palladium catalyzed asym allylic alkylation acyclic ketone.
The first example of Pd-catalyzed asym. allyl alkylation of the conformationally nonrigid acyclic ketone enolates is reported with excellent yields, regioselectivity, and enantioselectivity. The double bond geometry of the allyl enol carbonates affects its reactivity, selectivity, as well as the absolute configuration of the products. An opposite enantioselectivity from what is predicted by a direct attack of the enolate on the allyl moiety of the π-ally-Pd complex was observed An alternative mechanism was proposed, which involves an inner sphere process of coordination of the enolate to Pd followed by reductive elimination.
Journal of the American Chemical Society published new progress about Absolute configuration (product). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, HPLC of Formula: 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate