Trost, Barry M.; Xu, Jiayi published the artcile< Regio- and Enantioselective Pd-Catalyzed Allylic Alkylation of Ketones through Allyl Enol Carbonates>, Electric Literature of 152140-65-3, the main research area is enol allyl carbonate asym allylic alkylation palladium chiral ligand; palladium asym allylic alkylation catalyst; cyclic allylated ketone stereoselective preparation.
The Pd-catalyzed reorganization of enol allyl carbonates to allylated ketones occurs in the presence of chiral ligands that had been previously developed. With 2-methylcyclohexanone, asym. regioselective alkylation occurs at the more substituted carbon without complications of polyalkylation. Alkylation to create quaternary centers in indanones and benzosuberone occurs in much higher ee than using tin or lithium enolates. The sense of enantioinduction in tetralones is opposite from the tin and lithium enolate examples. For the first time, asym. preparation of tertiary centers occurs with high ee (78-99%). The different results between this reaction and the use of lithium or tin enolates suggest that different mechanisms may be involved.
Journal of the American Chemical Society published new progress about Allylic alkylation catalysts, stereoselective. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Electric Literature of 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate