Renom-Carrasco, Marc; Gajewski, Piotr; Pignataro, Luca; de Vries, Johannes G.; Piarulli, Umberto; Gennari, Cesare; Lefort, Laurent published the artcile< Asymmetric Hydrogenation of 3-Substituted Pyridinium Salts>, Category: chiral-phosphine-ligands, the main research area is pyridinium salt asym hydrogenation; asymmetric catalysis; homogeneous catalysis; hydrogenation; pyridines; reaction mechanisms.
The use of an equivalent amount of an organic base leads to high enantiomeric excess in the asym. hydrogenation of N-benzylated 3-substituted pyridinium salts into the corresponding piperidines. Indeed, in the presence of Et3N, a Rh-JosiPhos catalyst reduced a range of pyridinium salts with ee values up to 90%. The role of the base was elucidated with a mechanistic study involving the isolation of the various reaction intermediates and isotopic labeling experiments Addnl., this study provided some evidence for an enantiodetermining step involving a dihydropyridine intermediate.
Chemistry – A European Journal published new progress about Bases Role: RGT (Reagent), RACT (Reactant or Reagent). 277306-29-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C32H40FeP2, Category: chiral-phosphine-ligands.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate