Day: October 12, 2022

Zhang, Xiaoyong; Mashima, Kazushi; Koyano, Kinko; Sayo, Noboru; Kumobayashi, Hidenori; Akutagawa, Susumu; Takaya, Hidemasa published the artcile< Synthesis of partially hydrogenated BINAP variants>, Application of C44H40P2, the main research area is BINAP hydrogenated; crystal structure cyclohexylphosphinylbinaphthyl; mol structure cyclohexylphosphinylbinaphthyl; binaphthyl hydro atropisomeric phosphine ligand.

Three pairs of new axially dissym. diphosphine ligands, (R)-(-)- and (S)-(+)-2,2′-bis(dicyclohexylphosphino)-1,1′-binaphthyl, (R)-(+)- and (S)-(-)-2,2′-bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl and (R)-(-)- and (S)-(+)-2,2′-bis(dicyclohexylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, have been synthesized and their absolute configurations have been determined on the basis of an x-ray anal. and CD spectra.

Tetrahedron Letters published new progress about 139139-86-9. 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Application of C44H40P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Webster, Robert; Boeing, Christian; Lautens, Mark published the artcile< Reagent-controlled regiodivergent resolution of unsymmetrical oxabicyclic alkenes using a cationic rhodium catalyst>, Related Products of 277306-29-3, the main research area is dihydronaphthalenol derivative asym preparation; oxabenzonorbornene derivative preparation nucleophile ring opening reaction rhodium; rhodium asym ring opening reaction catalyst.

A Rh(I) catalyzed regiodivergent addition of heteroatom nucleophiles to racemic oxabicyclic alkenes produces good yields of regioisomeric products each in high ee. Powerful reagent control is demonstrated, as the inherent reactivity of the substrate is completely dominated by the chiral catalyst complex, which is shown to require the use of cationic Rh(I). The process affords rapid access to multiple 1,2-dihydronaphthalene products in high enantioselectivity from simple starting materials.

Journal of the American Chemical Society published new progress about Crystal structure. 277306-29-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C32H40FeP2, Related Products of 277306-29-3.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Yasui, Takeshi; Nakazato, Yuya; Kurisaki, Koutarou; Yamamoto, Yoshihiko published the artcile< Enantioselective Construction of 5-6-5 Tricyclic Lactone Framework Bearing a Quaternary Bridgehead Carbon via Rh-Catalyzed Asymmetric [2+2+2] Cycloaddition of Enediynes>, Name: (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is tricyclic cyclohexadiene lactone preparation enantioselective; enediyne cycloaddition rhodium catalyst.

Herein, a Rh-catalyzed asym. [2+2+2] cycloaddition of ene-yne-yne enediynes to generate enantio-enriched tricyclic cyclohexadienes bearing a quaternary bridgehead carbon is reported. The Rh-Phanephos complex is an appropriate catalyst for the cycloaddition of enediynes bearing an unsubstituted propiolate terminus, whereas Rh-biaryl bisphosphine catalysts, which have been widely used for asym. cycloadditions of alkynes and alkenes, are not applicable for the reaction of such enediynes. Several control experiments suggest that the reaction using the Rh-Phanephos complex exclusively proceeds via a rhodacyclopentadiene intermediate, unlike when using a Rh-biaryl bisphosphine complex that can form a rhodacyclopentadiene intermediate as well as a rhodacyclopentene intermediate in a substrate-dependent manner.

Advanced Synthesis & Catalysis published new progress about [2+2+2] Cycloaddition reaction (stereoselective). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Name: (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Duan, Ying; Chen, Mu-Wang; Ye, Zhi-Shi; Wang, Duo-Sheng; Chen, Qing-An; Zhou, Yong-Gui published the artcile< An enantioselective approach to 2,3-disubstituted indolines through consecutive Bronsted Acid/Pd-complex-promoted tandem reactions>, Name: (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is indoline chiral preparation tandem condensation asym hydrogenation indole aldehyde; hydrogenation catalyst asym palladium BINAP SynPhos complex indoline preparation; indole alkylation reductive tandem preparation chiral indoline.

Chiral substituted indolines, R1-2-R2-3-CH2R3-2,3-dihydro-1H-indoles (3, R1 = H, 5-F, 7-Me; R2 = Me, Bu, CH2CH2Ph; R3 = Ph, 4-MeOC6H4, 4-FC6H4, cyclohexyl, iPr) were prepared by tandem aldol addition-asym. hydrogenation reaction of R1-2-R2-1H-indoles with aldehydes R3CHO, catalyzed by TsOH and Pd-BINAP complexes. The reaction mechanism comprises Bronsted acid-catalyzed condensation and formation of 3-alkylideneiminium intermediate, which is then hydrogenated by in situ formed palladium diphosphine complexes, the (R)-H8-BINAP and (R)-SynPhos [2,2′,3,3′-tetrahydro[5,5′-bi-1,4-benzodioxin]-6,6′-bis(diphenylphosphine)] being the most effective ligands.

Chemistry – A European Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Name: (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Yasuda, Shigeo; Kawaguchi, Yasuaki; Okamoto, Yuta; Mukai, Chisato published the artcile< Chemo- and Regioselective Rhodium(I)-Catalyzed [2+2+2] Cycloaddition of Allenynes with Alkynes>, SDS of cas: 139139-93-8, the main research area is allenyne alkyne rhodium cycloaddition catalyst; benzene fused bicyclic preparation; alkynes; allenes; cycloaddition; regioselectivity; rhodium.

A highly chemo- and regioselective partially intramol. rhodium(I)-catalyzed [2+2+2] cycloaddition of allenynes with alkynes is described. A range of diverse polysubstituted benzene derivatives could be synthesized in good to excellent yields, in which the allenynes served as synthetic equivalent to the diynes. A high regioselectivity could be observed when allenynes were treated with unsym. alkynes.

Chemistry – A European Journal published new progress about [2+2+2] Cycloaddition reaction. 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, SDS of cas: 139139-93-8.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Tian, Shengjun; Wang, Jianjun; Jonas, Ulrich; Knoll, Wolfgang published the artcile< Inverse Opals of Polyaniline and Its Copolymers Prepared by Electrochemical Techniques>, COA of Formula: C21H27N7Na2O14P2, the main research area is polyaniline composite inverse opal electrochem preparation electrocatalyst.

Ordered 3D arrays of polyaniline (PANI) inverse opals were fabricated via electrochem. methods by using colloidal crystals of polystyrene beads as sacrificial templates. Compared with films obtained by chem. synthesis, the inverse opaline samples obtained by electrochem. had a much higher structural quality. To explore potential biosensing applications, PANI composite inverse opals were fabricated for the first time by modifying the structure with different dopants, such as poly(acrylic acid) (PAA) and poly(styrene sulfonate) (PSS). It was found that these dopants had a major effect on the structure of the obtained opaline films. With selection of suitable dopants, PANI composite inverse opals could be fabricated with very high quality. The obtained films remained electroactive in buffer solutions of neutral pH. Owing to their huge surface area, they should be ideal candidates for biosensing applications, e.g., as electrocatalysts or bioreactors. Our first effort to use such macroporous structures as electrocatalysts for the oxidation of reduced β-NAD (NADH) showed that the electrocatalytic efficiency of the inverse opaline film was much higher compared with that of an unpatterned film.

Chemistry of Materials published new progress about Colloidal crystals. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, COA of Formula: C21H27N7Na2O14P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Lautens, Mark; Fagnou, Keith; Rovis, Tomislav published the artcile< Rhodium-Catalyzed Asymmetric Alcoholysis and Aminolysis of Oxabenzonorbornadiene: A New Enantioselective Carbon-Heteroatom Bond Forming Process>, Name: (2S)-1-[(1S)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene, the main research area is oxabenzonorbornadiene rhodium catalyzed stereoselective ring opening; alcoholysis stereoselective rhodium catalyzed oxabenzonorbornadiene; aminolysis stereoselective rhodium catalyzed oxabenzonorbornadiene; naphthalenol stereoselective preparation; aminonaphthalenol stereoselective preparation.

The Rh-catalyzed asym. ring-opening of oxabenzonorbornadienes with alcs. and N nucleophiles produced trans-2-alkoxy- and amino-1,2-dihydro-1-naphthols in good yield and ≤99% ee. The effects of substituents on the aromatic ring were investigated.

Journal of the American Chemical Society published new progress about Alcoholysis (stereoselective). 277306-29-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C32H40FeP2, Name: (2S)-1-[(1S)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Oonishi, Yoshihiro; Masusaki, Shuichi; Sakamoto, Shunki; Sato, Yoshihiro published the artcile< Rhodium(I)-Catalyzed Enantioselective Cyclization of Enynes by Intramolecular Cleavage of the Rh-C Bond by a Tethered Hydroxy Group>, Reference of 139139-93-8, the main research area is acyl heterocyclic compound enantioselective preparation; enynol preparation enantioselective cyclization rhodium catalyst; cyclization; enantioselectivity; enyne; rhodium; σ-bond metathesis.

Rhodium(I)-catalyzed enantioselective intramol. cyclization of enynes having a hydroxy group in the tether was investigated, and various cyclic compounds possessing a chiral quaternary carbon center were obtained in high yields with high ees. In this cyclization, a Rh-C(sp2) bond in the rhodacyclopentene intermediate, which was formed by enantioselective oxidative cycloaddition of enynes to a chiral rhodium(I) complex, was intramolecularly cleaved by σ-bond metathesis of a tethered O-H bond in the substrate. Furthermore, it was found that the cyclic compounds were obtained with high ees even when the starting materials having a racemic secondary alc. moiety were used in this reaction.

Angewandte Chemie, International Edition published new progress about Alcohols, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Reference of 139139-93-8.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Seraphim, Thiago V.; Nano, Nardin; Cheung, Yiu Wing Sunny; Aluksanasuwan, Siripat; Colleti, Carolina; Mao, Yu-Qian; Bhandari, Vaibhav; Young, Gavin; Holl, Larissa; Phanse, Sadhna; Gordiyenko, Yuliya; Southworth, Daniel R.; Robinson, Carol V.; Thongboonkerd, Visith; Gava, Lisandra M.; Borges, Julio C.; Babu, Mohan; Barbosa, Leandro R. S.; Ramos, Carlos H. I.; Kukura, Philipp; Houry, Walid A. published the artcile< Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes>, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt, the main research area is chaperone complex Armadillo repeat domain folded protein; AAA+ proteins; ATPases; PAQosome; R2TP; RUVBL1/2; macromolecular complex assembly; molecular chaperones; protein folding.

R2TP is a highly conserved chaperone complex formed by two AAA+ ATPases, RUVBL1 and RUVBL2, that associate with PIH1D1 and RPAP3 proteins. R2TP acts in promoting macromol. complex formation. Here, we establish the principles of R2TP assembly. Three distinct RUVBL1/2-based complexes are identified: R2TP, RUVBL1/2-RPAP3 (R2T), and RUVBL1/2-PIH1D1 (R2P). Interestingly, we find that PIH1D1 does not bind to RUVBL1/RUVBL2 in R2TP and does not function as a nucleotide exchange factor; instead, RPAP3 is found to be the central subunit coordinating R2TP architecture and linking PIH1D1 and RUVBL1/2. We also report that RPAP3 contains an intrinsically disordered N-terminal domain mediating interactions with substrates whose sequences are primarily enriched for Armadillo repeat domains and other helical-type domains. Our work provides a clear and consistent model of R2TP complex structure and gives important insights into how a chaperone machine concerned with assembly of folded proteins into multisubunit complexes might work.

Structure (Oxford, United Kingdom) published new progress about A-kinase anchor protein 4 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Tang, Liang L.; Ryabov, Alexander D.; Collins, Terrence J. published the artcile< Kinetic Evidence for Reactive Dimeric TAML Iron Species in the Catalytic Oxidation of NADH and a Dye by O2 in AOT Reverse Micelles>, Application of C21H27N7Na2O14P2, the main research area is kinetics reactive dimeric TAML iron species; catalytic oxidation NADH dye oxygen AOT reverse micelle.

The efficacy of the iron(III) TAML activator [Fe{C6H4-1,2-(N1COCMe2N2CO)2CMe2(Fe-N1)(Fe-N2)}(OH2)]- (1) for the catalytic activation of dioxygen in reverse micelles of Aerosol OT (AOT) in n-octane has been studied. Kinetic evidence is presented for the existence of unusual second-order catalytic pathways in the oxidation of NADH to NAD+ and the bleaching of blue pinacyanol chloride (PNC) dye. Depending on the substrate and reaction conditions, a second-order pathway in [1] either dominates or proceeds in obvious combination with a first-order pathway in [1]. Detailed kinetic anal. of the exptl. data supports the previously made hypothesis that the reactive intermediate is associated with the mixed-valent dimer system [LFeIIIOFeIVL]3-/[LFeIII(OH)FeIVL]2-.

ACS Catalysis published new progress about Bleaching. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Application of C21H27N7Na2O14P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate