Augustine, Robert; Tanielyan, Setrak; Marin, Norman; Alvez, Gabriela published the artcile< Synthesis of chiral 2-amino-1-phenylethanol>, Application of C48H50P2, the main research area is aminophenylethanol stereoselective preparation phenacyl chloride.
Two methods for the synthesis of chiral 2-amino-1-phenylethanol have been developed. The first uses a chiral oxaborolidine catalyzed borane reduction of phenacyl chloride to give the chiral chloro alc. in very good yield with an ee in the 93%-97% range. Reaction with dilute ammonium hydroxide produced the amino alc. in very good yield with a high ee. The second approach involved the conversion of phenacyl chloride to the succinimide which was then hydrogenated using a chiral ruthenium complex in conjunction with a base and an optically active amine (Noyori procedure) to give the optically active succinimido alc. in very good yield with an ee of 98%. Hydrolysis with dilute base produced the optically active amino alc. in very good yield and excellent enantioselectivity.
Chemical Industries (Boca Raton, FL, United States) published new progress about Chiral ligands Role: CAT (Catalyst Use), USES (Uses). 325168-88-5 belongs to class chiral-phosphine-ligands, and the molecular formula is C48H50P2, Application of C48H50P2.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate