Akula, Ramulu; Guiry, Patrick J. published the artcile< Enantioselective Synthesis of α-Allyl-α-aryldihydrocoumarins and 3-Isochromanones via Pd-Catalyzed Decarboxylative Asymmetric Allylic Alkylation>, COA of Formula: C54H42N2O2P2, the main research area is decarboxylative asym allylation of aryl oxo ester; enantioselective synthesis allyl aryl dihydrocoumarin; isochromanone allyl aryl enantioselective synthesis; crystal structure.
An enantioselective Pd-catalyzed decarboxylative asym. allylic alkylation (DAAA) of α-aryl-β-oxo esters has been developed employing the (R,R)-ANDEN-Ph Trost ligand to prepare a series of α-aryl-α-allyldihydrocoumarins and 3-isochromanones. A variety of aryl groups were successfully employed to afford the dihydrocoumarin and 3-isochromanone products in high yields up to 95% and ee’s up to 96%. Under these conditions, substrates containing di- and mono-o-substituted aryl groups gave the highest levels of enantioselectivities. This work represents the first example of the enantioselective preparation of all-carbon quaternary α-allyl-α-aryl dihydrocoumarins and 3-isochromanones.
Organic Letters published new progress about Allylation catalysts. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, COA of Formula: C54H42N2O2P2.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate