Trost, Barry M.; Nagaraju, Anugula; Wang, Feijun; Zuo, Zhijun; Xu, Jiayi; Hull, Kami L. published the artcile< Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones>, Application of C54H42N2O2P2, the main research area is palladium catalyst decarboxylative asym allylic alkylation dihydroquinolinone.
A palladium-catalyzed decarboxylative asym. allylic alkylation (Pd-DAAA) of benzo-fused and non-benzo-fused δ-valerolactams is disclosed. This methodol. gives access to chiral lactams bearing C3-quaternary stereocenters, which are central to many natural products and biol. active compounds The reaction proceeds via palladium-catalyzed ionization of an allyl ester, followed by carbon dioxide extrusion and recombination of the electrophilic Pd-π-allyl complex with the in situ generated lactam enolate. This final step converts racemic allylic ester starting materials into enantiomerically enriched substituted lactams with high yield and enantiomeric excess.
Organic Letters published new progress about Allylic alkylation catalysts, stereoselective. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Application of C54H42N2O2P2.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate