Chen, Yi; Song, Xuanyi; Gao, Lu; Song, Zhenlei published the artcile< Intramolecular Sakurai Allylation of Geminal Bis(silyl) Enamide with Indolenine. A Diastereoselective Cyclization To Form Functionalized Hexahydropyrido[3,4-b]Indole>, HPLC of Formula: 152140-65-3, the main research area is Sakurai allylation enamide indolenine diastereoselective cyclization; hexahydropyridoindole diastereoselective synthesis; akuammiline alkaloid core synthesis Sakurai allylation fluoride.
A fluoride-promoted intramol. Sakurai allylation of geminal bis(silyl) enamide with indolenine has been developed. The reaction facilitates an efficient cyclization to give hexahydropyrido[3,4-b]indoles in good yields with high diastereoselectivity. The resulted cis,trans-stereochem. further enables the ring-closing metathesis (RCM) reaction of two alkene moieties, giving a tetracyclic N-heterocycle I widely found as the core structure in akuammiline alkaloids.
Organic Letters published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (akuammiline core structure). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, HPLC of Formula: 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate