Koch, Guido et al. published new progress in experiments with the help of cas: 167693-62-1

(S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole(cas: 167693-62-1) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.Recommanded Product: 167693-62-1

Koch, Guido;Lloyd-Jones, Guy C.;Loiseleur, Olivier;Pfaltz, Andreas;Pretot, Roger;Schaffner, Siliva;Schnider, Patrick;von Matt, Peter published 《Synthesis of chiral (phosphinoaryl)oxazolines, a versatile class of ligands for asymmetric catalysis》. The research results were published in《Recueil des Travaux Chimiques des Pays-Bas》 in 1995.Recommanded Product: 167693-62-1 The article conveys some information:

Enantiomerically pure 2-[2-(diphenylphosphino)aryl]oxazolines I (R = Ph, CHMe2, CMe3, CH2Ph, isobutyl) are readily prepared from 2-bromobenzonitrile by transmetalation with BuLi, subsequent reaction with chlorodiphenylphosphine and conversion of the resulting phosphinoaryl nitrile to the oxazoline by treatment with a chiral amino alc. in the presence of ZnCl2. An alternative synthesis is based on the ortho-metalation of 2-aryloxazolines followed by reaction with chlorodiphenylphosphine.(S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole (cas: 167693-62-1) were involved in the experimental procedure.

(S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole(cas: 167693-62-1) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.Recommanded Product: 167693-62-1

Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis