Gonzalez-Esguevillas, Maria;Pascual-Escudero, Ana;Adrio, Javier;Carretero, Juan C. published 《Highly selective copper-catalyzed asymmetric [3+2] cycloaddition of azomethine ylides with acyclic 1,3-dienes》 in 2015. The article was appeared in 《Chemistry – A European Journal》. They have made some progress in their research.COA of Formula: C48H28F24O4P2 The article mentions the following:
The first examples of the catalytic asym. 1,3-dipolar cycloaddition of azomethine ylides with acyclic activated 1,3-dienes/1,3-enynes was described. Under copper catalysis, a selective cycloaddition at the terminal γ,δ-C=C bond was observed In addition, depending on the ligand used, either the exo or endo adduct of pyrrolidines e.g.I [Ar = C6H5, 4-MeC6H4, 2-BrC6H4, etc.] could be obtained with high selectivity. Under appropriate reaction conditions, the acyclic 1,6-addition product was detected, suggesting a stepwise mechanism. The resulting pyrrolidines were suitable substrates for further access to polycyclic systems, as highlighted by the preparation of hexahydrochromeno[4,3-b]pyrrole and the tetracyclic core of the alkaloid gracilamine.(R)-2,2′-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl (cas: 1365531-84-5) were involved in the experimental procedure.
(R)-2,2′-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl(cas: 1365531-84-5) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.COA of Formula: C48H28F24O4P2
Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis