Recommanded Product: 34031-32-8《The thioredoxin reductase inhibitor auranofin suppresses pulmonary metastasis of osteosarcoma, but not local progression》 was published in 2021. The authors were Kinoshita, Hideyuki;Shimozato, Osamu;Ishii, Takeshi;Kamoda, Hiroto;Hagiwara, Yoko;Tsukanishi, Toshinori;Ohtori, Seiji;Yonemoto, Tsukasa, and the article was included in《Anticancer Research》. The author mentioned the following in the article:
Auranofin (AUR), a thioredoxin reductase (TXNRD) inhibitor, shows anticancer activity against several cancers. This study investigated the effects of AUR on the local progression and pulmonary metastasis of osteosarcoma (OS). Publicly available expression cohorts were analyzed to study the relationship between TXNRD-2 expression and the survival of patients with OS. The murine OS cell line LM8 was stimulated with AUR. Cell viability, apoptosis-related protein levels, caspase activity, and wound healing were analyzed. Tumor progression and pulmonary metastasis were investigated in C3H mice implanted with LM8 cells. High-level expression of TXNRD-2 represented a neg. prognostic factor for metastasis and overall survival in patients with OS. AUR induced apoptosis of OS cells via the oxidative stress-MAPK-Caspase 3 pathway, and suppressed the migration of OS cells. AUR inhibited the pulmonary metastasis of OS, but not local progression. AUR represents a potential therapeutic drug for suppressing pulmonary metastasis of OS. The experimental procedure involved many compounds, such as ((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-thio)(triethylphosphine)gold (cas: 34031-32-8) .
((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-thio)(triethylphosphine)gold(cas: 34031-32-8) is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase.Recommanded Product: 34031-32-8
Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis