So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tietze, Lutz F.; Wiegand, J. Matthias; Vock, Carsten researched the compound: trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium( cas:172418-32-5 ).Safety of trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium.They published the article 《Synthesis of enantiopure B-nor-steroids by multiple Pd-catalyzed transformations》 about this compound( cas:172418-32-5 ) in Journal of Organometallic Chemistry. Keywords: steroid B nor preparation palladium catalyzed Suzuki coupling; Heck reaction intramol microwave palladium catalyzed B norsteroid preparation. We’ll tell you more about this compound (cas:172418-32-5).
The synthesis of the novel enantiopure B-nor-steroid I is described employing a combination of a Suzuki- and a Heck-reaction. As substrates the 2-bromobenzyl chloride and the boronic ester II were used; the latter was prepared from the Hajos-Wiechert ketone derivative in five steps. Noteworthy, the Heck-reaction was performed under microwave irradiation, which was much superior compared to the normal thermal reaction. The purpose of the described work is the design of novel estrogens, which bind to the β-unit of the maxi K+-channel located on the surface of the endothelium without showing the hormonal activity of estradiol.
This compound(trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium)Safety of trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate