Name: trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium, is researched, Molecular C46H46O4P2Pd2, CAS is 172418-32-5, about Palladium-catalyzed reactions for fine chemical synthesis. Part 4. Phosphapalladacycle-catalyzed Heck reactions for efficient synthesis of trisubstituted olefins. Evidence for palladium(0) intermediates. Author is Beller, Matthias; Riermeier, Thomas H..
The Heck coupling reaction of 1,1-disubstituted olefins with various aryl bromides was studied as a new concept to synthesize trisubstituted olefins. Surprisingly, the nature of the base dramatically influences the product distribution. Thus, a systematic investigation on the role of base in Heck reactions of 1,1-disubstituted olefins was performed. Less-coordinating bases like NaOAc, NaOBz, or Na2CO3 yield a statistical distribution of regioisomers with the terminal olefin as the major product. However, by using amines like Bu3N or EtN(CHMe2)2 (DIPEA) as base, internal olefins can be synthesized with high selectivities. With trans-di(μ-acetato)bis[2-(di-2-tolylphosphinyl)benzyl]dipalladium(II) (I) as catalyst precursor, catalyst turnover numbers ≤1000 were obtained, while Pd(OAc)2/2PPh3 was one order of magnitude less active. Anal. of the reaction profile by kinetic investigations led to the postulation of a reduction and subsequent oxidative addition of the catalyst precursor I to form {Pd[P(C6H4-2-Me)3](4-ClC6H4)(Br)}2 as catalytically active intermediate, which was prepared from Pd[P(C6H4-2-Me)3] and 4-ClC6H4Br.
《Palladium-catalyzed reactions for fine chemical synthesis. Part 4. Phosphapalladacycle-catalyzed Heck reactions for efficient synthesis of trisubstituted olefins. Evidence for palladium(0) intermediates》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium)Name: trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate