Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 49609-84-9, is researched, SMILESS is O=C(Cl)C1=CC=CN=C1Cl, Molecular C6H3Cl2NOJournal, Article, Scientific Reports called Dual-active antifungal agents containing strobilurin and SDHI-based pharmacophores, Author is Zuccolo, Marco; Kunova, Andrea; Musso, Loana; Forlani, Fabio; Pinto, Andrea; Vistoli, Giulio; Gervasoni, Silvia; Cortesi, Paolo; Dallavalle, Sabrina, the main research direction is Pyricularia Sclerotinia strobilurin SDHi pharmacophore antifungal.Recommanded Product: 2-Chloronicotinoyl chloride.
Crop disease management often implies repeated application of fungicides. However, the increasing emergence of fungicide-resistant pathogens requires their rotation or combined use. Tank-mix combinations using fungicides with different modes of action are often hard to manage by farmers. An alternative and unexploited strategy are bifunctional fungicides, i.e. compounds resulting from conjugation of the pharmacophores of fungicides with different mechanisms of action. In this paper we describe a new approach to antifungal treatments based on the synthesis of dual agents, obtained by merging the strobilurin and succinate dehydrogenase inhibitor pharmacophores into a new entity. The compounds were tested against important fungal plant pathogens and showed good inhibition of Pyricularia oryzae and Sclerotinia sclerotiorum with activity comparable to com. fungicides. The inhibition of the cytochrome bc1 and the succinate dehydrogenase enzyme activity confirmed that the new mols. are endowed with a dual mechanism of action. These results were further supported by mol. modeling which showed that selected compounds form stable complexes with both cytochrome b subunit and succinate dehydrogenase enzyme. This work can be considered an important first step towards the development of novel dual-action agents with optimized structure and improved interaction with the targets.
Different reactions of this compound(2-Chloronicotinoyl chloride)Recommanded Product: 2-Chloronicotinoyl chloride require different conditions, so the reaction conditions are very important.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate