Endoori, Srinivas; Gulipalli, Kali Charan; Bodige, Srinu; Shaikh, Arbaz Sujat; Vemula, Divya; Surapureddi, Sri Ramakrishna; Seelam, Nareshvarma published the article 《Design, synthesis, anti-cancer activity and in-silico studies of some novel 4,5-dihydroisoxazole-5-carboxamide derivatives》. Keywords: dihydroisoxazole carboxamide preparation SAR mol docking antitumor human.They researched the compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ).Formula: C6H4ClNO. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:31181-89-2) here.
A novel series of 4,5-dihydroisoxazole-5-carboxamide derivatives I (X = CH, N; R = Cl, CF3; R1 = cyclobutyl, cyclohexyl, benzoyl, etc.) were designed, synthesized and evaluated for their anti-cancer activity against two different human cancer cell lines. Most of the synthesized compounds showed anti-cancer activity with IC50 values ranging from 4.03 to 104.45μM. Further, few compounds were showed potent inhibitory activity against two cancer cell lines, with IC50 values close to that of standard drug. It is important to note that compound I (X = CH; R = CF3; R1 = 5-isopropyl-3-yl-isoxazole) was more potent than the standard drug cisplatin with IC50 values of 4.11 and 4.03μM against Hela cell line and MCF-7 cell line resp.
After consulting a lot of data, we found that this compound(31181-89-2)Formula: C6H4ClNO can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate