Recommanded Product: 2-Chloronicotinoyl chloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3. Author is Ceballos, Javier; Schwalfenberg, Melanie; Karageorgis, George; Reckzeh, Elena S.; Sievers, Sonja; Ostermann, Claude; Pahl, Axel; Sellstedt, Magnus; Nowacki, Jessica; Carnero Corrales, Marjorie A.; Wilke, Julian; Laraia, Luca; Tschapalda, Kirsten; Metz, Malte; Sehr, Dominik A.; Brand, Silke; Winklhofer, Konstanze; Janning, Petra; Ziegler, Slava; Waldmann, Herbert.
Bioactive compound design based on natural product (NP) structure may be limited because of partial coverage of NP-like chem. space and biol. target space. These limitations can be overcome by combining NP-centered strategies with fragment-based compound design through combination of NP-derived fragments to afford structurally unprecedented “”pseudo-natural products”” (pseudo-NPs). The design, synthesis, and biol. evaluation of a collection of indomorphan pseudo-NPs that combine biosynthetically unrelated indole- and morphan-alkaloid fragments are described. Indomorphane derivative glupin (I) was identified as a potent inhibitor of glucose uptake by selectively targeting and upregulating glucose transporters GLUT-1 and GLUT-3. Glupin suppresses glycolysis, reduces the levels of glucose-derived metabolites, and attenuates the growth of various cancer cell lines. Our findings underscore the importance of dual GLUT-1 and GLUT-3 inhibition to efficiently suppress tumor cell growth and the cellular rescue mechanism, which counteracts glucose scarcity.
After consulting a lot of data, we found that this compound(49609-84-9)Recommanded Product: 2-Chloronicotinoyl chloride can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate