Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Organic & Biomolecular Chemistry called Superbase-promoted selective carbon-carbon bond cleavage driven by aromatization, Author is Liu, Can; Zhu, Xianjin; Han, Yongzhen; Yang, Haijun; Zhu, Changjin; Fu, Hua, which mentions a compound: 40400-13-3, SMILESS is BrCC1=C(I)C=CC=C1, Molecular C7H6BrI, Electric Literature of C7H6BrI.
A novel selective carbon-carbon single bond cleavage has been disclosed through the copper-catalyzed reaction of 1-alkyl-3-alkylindolin-2-imine hydrochlorides I•HCl (R1 = 7-CH3, 5-OCH3, 5-Cl, etc.; R2 = CH3, CH2C6H5, CH2CH=CH2, etc.; R3 = C2H5, CH2C6H5, 4-ClC6H4CH2, etc.) with substituted 1-(bromomethyl)-2-iodobenzenes R4-2-(X)C6H3CH2Br (R4 = H, 5-OCH3, 4-F, 5-F, 5-Cl; X = I, Br) leading to fused N-heterocycles II (R5 = 7-CH3, 9-OCH3, 9-Cl, etc.; R6 = 2-OCH3, 3-F, 2-F, 2-Cl). Mechanistic studies showed that the intrinsic drive of aromatization and the action of the superbase derived from sodium tert-butoxide and dimethylsulfoxide were the key factors leading to the carbon-carbon single bond cleavage. Furthermore, the obtained N-heterocycles are indoloquinoline derivatives II with wide biol. activities.
After consulting a lot of data, we found that this compound(40400-13-3)Electric Literature of C7H6BrI can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate