Computed Properties of C6H3Cl2NO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Enantioselective Addition of Azlactones to Ethylene Sulfonyl Fluoride via Dual Catalysis. Author is Zhu, Dong-yu; Zhang, Xue-jing; Yan, Ming.
Enantioselective conjugate addition of azlactones I (R1 = Me, Ph, 2-BrC6H4, 2-furyl, 2-chloro-3-pyridinyl, etc.; R2 = Ph, PhCH2, 1-naphthylmethyl, 3-indolylmethyl, etc.) to vinylsulfonyl fluoride has been achieved via the cooperative catalysis with (DHQD)2PHAL and a hydrogen-bond donor (HBD). This approach furnishes a facile access to a range of structurally diverse azlactone sulfonyl fluoride derivatives II in good to excellent yields and enantioselectivities. The combination of azlactone and sulfonyl fluoride group produces valuable unnatural α-quaternary amino acid derivatives for the drug discovery.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate