In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Thiophene Derivative-Loaded Nanoparticles Mediate Anticancer Activity Through the Inhibition of Kinases and Microtubule Assembly, published in 2021-07-31, which mentions a compound: 40400-13-3, mainly applied to thiophene nanoparticle anticancer kinase inhibition microtubule assembly; Antimitotic drugs; Caspase activity; Cell cycle arrest; Microtubule assembly; Nanoparticles; Tetrahydrobenzo[b]thiophenes; Tubulin polymerization, COA of Formula: C7H6BrI.
Different tetrahydrobenzo[b]thiophene derivatives are explored as new tubulin polymerization destabilizers to arrest tumor cell mitosis. A series of compounds incorporating the tetrahydrobenzo[b]thiophene scaffold are synthesized, and their biol. activities are investigated. The cytotoxicity of each of the synthesized compounds is assessed against a range of cell lines. Specifically, the benzyl urea tetrahydrobenzo[b]thiophene derivative, 1-benzyl-3-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)urea (BU17), is identified as the most potent compound with broad-spectrum antitumor activity against several cancer cell lines. The potential mechanism(s) of action are investigated where dose-dependent G2/M accumulation and A549 cell cycle arrest are detected. Addnl., A549 cells treated with BU17 express enhanced levels of caspase 3 and 9, indicating the induction of apoptosis. Furthermore, it is found that BU17 inhibits WEE1 kinase and targets tubulin by blocking its polymerization BU17 is also formulated into PLGA nanoparticles, and it is demonstrated that BU17-loaded nanoparticles can significantly enhance antitumor activity compared to the soluble counterpart.
Compounds in my other articles are similar to this one(1-(Bromomethyl)-2-iodobenzene)COA of Formula: C7H6BrI, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate