Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Preprint, ChemRxiv called Mapping ambiphile reactivity trends in the anti-(hetero)annulation of non-conjugated alkenes via Pd(II)/Pd(IV) catalysis, Author is Ni, Hui-Qi; Cooper, Phillippa; Yang, Shouliang; Wang, Fen; Sach, Neal; Bedekar, Pranali G.; Donaldson, Joyann S.; Tran-Dube, Michelle; McAlpine, Indrawan J.; Engle, Keary M., which mentions a compound: 40400-13-3, SMILESS is BrCC1=C(I)C=CC=C1, Molecular C7H6BrI, Recommanded Product: 1-(Bromomethyl)-2-iodobenzene.
A systematic evaluation of different ambiphilic organohalides, e.g., N-(2-iodobenzyl)-4-(trifluoromethyl)benzenesulfonamide for their ability to participate in anti-selective carbo- or heteroannulation with non-conjugated alkenyl amides e.g., N-(quinolin-8-yl)but-3-enamide under Pd catalysis has been described. Detailed optimization of reaction conditions has led to protocols for synthesizing tetrahydropyridines I (R = H, Me; R1 = H, Me, Ph; X = tosyl, 4-CNC6H4S(O)2), tetralins II [R2 = H, Me, OMe, etc.; R3 = H, CN; R4 = C(C(O)OMe)2, C(C(O)OEt)2, C(CN)(C(O)OEt), etc.], pyrrolidines III (R5 = Ts, OBn, Ph), and other carbo/heterocyclic cores via [n + 2] (n = 3-5) (hetero)annulation. Expansion of scope to otherwise unreactive ambiphilic haloketones through Pd(II)/amine co-catalysis is also demonstrated. Compared to other annulation processes, this method proceeds via a distinct Pd(II)/Pd(IV) mechanism involving Wacker type directed nucleopalladation. This distinction results in unique reactivity and selectivity patterns, as revealed through assessment of reaction scope and competition experiments
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate