The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ) is researched.Product Details of 40400-13-3.Chang, Chenyang; Zhang, Huihui; Wu, Xinxin; Zhu, Chen published the article 《Radical trifunctionalization of hexenenitrile via remote cyano migration》 about this compound( cas:40400-13-3 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: hexenenitrile radical trifunctionalization remote cyano migration. Let’s learn more about this compound (cas:40400-13-3).
A novel radical-mediated trifunctionalization of hexenenitriles via the strategy of remote functional group migration is disclosed. A portfolio of functionalized hexenenitriles are employed as substrates. After difunctionalization of the unactivated alkenyl part via remote cyano migration, the in situ formed radical intermediate is captured by an azido radical, thus enabling the trifunctionalization. The reaction features mild conditions and broad functional group compatibility, leading to valuable products bearing multiple useful groups. This protocol further extends the scope of remote functional group migration.
Compounds in my other articles are similar to this one(1-(Bromomethyl)-2-iodobenzene)Product Details of 40400-13-3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate