Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 172418-32-5, is researched, SMILESS is CC1=C([P]2([Pd+2]3([CH2-]C4=C2C=CC=C4)[O-]/C(C)=O[Pd+2]5([O-]/C(C)=O3)[P](C6=C(C)C=CC=C6)(C7=C([CH2-]5)C=CC=C7)C8=C(C)C=CC=C8)C9=C(C)C=CC=C9)C=CC=C1, Molecular C46H46O4P2Pd2Journal, Article, Chemistry – A European Journal called Palladium-catalyzed reactions for fine chemical synthesis. Part 20. Palladium catalyst systems for cross-coupling reactions of aryl chlorides and olefins, Author is Zapf, Alexander; Beller, Matthias, the main research direction is Heck coupling reaction trifluoromethylchlorobenzene olefin.SDS of cas: 172418-32-5.
A detailed investigation into the influence of phosphines, additives, bases, and solvents on the Heck coupling reaction of 4-trifluoromethyl-1-chlorobenzene is presented. It is shown that a number of catalyst systems exist for efficient cross coupling of electron-deficient aryl chlorides with various olefins. Basicity and steric demand of the ligand are two factors which determine the success of the reaction. In addition the phosphine/palladium ratio, the correct type and amount of additive, and finally the use of an appropriate base and solvent are also important. The optimized reaction conditions are applied for the arylation of styrene, 2-ethylhexyl acrylate and N,N-di-Me acrylic amide with various aryl chlorides.
As far as I know, this compound(172418-32-5)SDS of cas: 172418-32-5 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate