Extracurricular laboratory: Synthetic route of 172418-32-5

Compounds in my other articles are similar to this one(trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium)Synthetic Route of C46H46O4P2Pd2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Synthetic Route of C46H46O4P2Pd2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium, is researched, Molecular C46H46O4P2Pd2, CAS is 172418-32-5, about NC-palladacycles as highly effective cheap precursors for the phosphine-free Heck reactions. Author is Beletskaya, I. P.; Kashin, A. N.; Karlstedt, N. B.; Mitin, A. V.; Cheprakov, A. V.; Kazankov, G. M..

Eight cyclopalladated complexes [Pd2(μ-L)2(N-C)2] (L = OAc, Cl; N-C = cyclometalated N donor: o-(2-pyridyl)phenyl, o-(2-pyridyloxy)phenyl, o-(2-pyridylmethyl)phenyl, o-(N,N-dimethylaminomethyl)phenyl, 8-quinolylmethyl and others) and a six-membered palladacycle with OC coordination (ligand related to 2-acetamido-4-nitrophenyl), are highly efficient catalysts for the Heck arylation of olefins (styrene, Et acrylate) by aryl halides (iodobenzene, bromobenzene, 4-bromoacetophenone). These catalysts are air stable, easy to obtain from a vast number of readily available nitrogen-containing mols., are generally much cheaper than phosphine-ligated palladacycles, but are as or more efficient than the latter. Turnover numbers (ton) of up to 4100000 and turnover frequencies (tof) up to 530000 are achieved in the reaction of iodobenzene with Et acrylate. Bromobenzene undergoes the Heck reaction (ton = 400-700; tof = 5-30) in the presence of the promoter additive Bu4NBr. The palladacycles probably operate in a common phosphine-free Pd(0)/Pd(II) catalytic cycle, while the differences between various types of palladacycle precursors are accounted for by the kinetics of the catalyst preactivation step.

Compounds in my other articles are similar to this one(trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium)Synthetic Route of C46H46O4P2Pd2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate