The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol(SMILESS: O[C@H]([C@H]([C@H]([C@@H](CO)O1)O)O)[C@@H]1OC,cas:1824-94-8) is researched.Computed Properties of C6H4ClNO. The article 《Evaluation and optimization of sample pretreatment for GC/MS-based metabolomics in embryonic zebrafish》 in relation to this compound, is published in Talanta. Let’s take a look at the latest research on this compound (cas:1824-94-8).
Metabolomics tactics have been applied in the research associated with embryonic zebrafish. However, the report regarding the evaluation of impacts of sample pretreatment on metabolomics results from zebrafish embryos is limited. Different data normalization approaches, extraction solvents, and extraction strategies for off-line derivatization gas chromatog. coupled with mass spectrometry-based metabolomics anal. of zebrafish eleutheroembryos were evaluated and optimized. When 4-chlorophenylalanine normalization, sample homogenization and pure methanol combined with ultrasonic extraction were conducted, better repeatabilities, higher signals and broader coverages of detected metabolites can be achieved. The recovery and standard deviation of most standards were at 82-121% and 6.6%-12%, resp., while the relative standard deviation of major detected metabolites ranged from 5.4% to 19%, indicating good extraction efficiencies and method precision. Under the developed method, 87 important endogenous metabolites such as citric acid and hypoxanthine were identified by universal databases or standards among 270 extracted metabolites, which consisted of sugars, amines, amino acids, nucleotides, fatty acids, and sterols. Therefore, the results could provide a proper pretreatment protocol for the anal. of wide-coverage metabolome in embryonic zebrafish. In addition, this study highlights the impact of normalization and extraction methods on the data quality of metabolomics anal.
In addition to the literature in the link below, there is a lot of literature about this compound((2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol)Synthetic Route of C7H14O6, illustrating the importance and wide applicability of this compound(1824-94-8).
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate