Bi, Weiyang; Yang, Yunhui; Ye, Song; Wang, Congyang published the article 《Umpolung coupling of pyridine-2-carboxaldehydes and propargylic carbonates via N-heterocyclic carbene/palladium synergetic catalysis》. Keywords: pyridine carboxaldehyde propargylic carbonate palladium NHC coupling catalyst; propargylic ketone preparation.They researched the compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ).Synthetic Route of C6H4ClNO. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:31181-89-2) here.
The umpolung cross-coupling reaction of pyridine-2-carboxaldehydes and propargylic carbonates has been developed for the first time through N-heterocyclic carbene/palladium cooperative catalysis with the judicious selection of the palladium catalyst, ligand and N-heterocyclic carbene, giving the propargylic ketones, I (R1 = H, 6-Me, 5-Cl, 3-F, etc.; R2 = Ph, 4-FC6H4, 4-MeC6H4, 2-MeOC6H4, n-Bu, 2-naphthyl, etc.) regioselectively.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate