Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Palladium-Catalyzed Synthesis of 6H-Dibenzo[c,h]chromenes and 5,6-Dihydrobenzo[c]phenanthridines: Application to the Synthesis of Dibenzo[c,h]chromene-6-ones, Benzo[c]phenanthridines, and Arnottin I.Formula: C7H6BrI.
6H-Dibenzo[c,h]chromenes, e.g. I, and N-tosyl-5,6-dihydrobenzo[c]phenanthridines II [R1 = H, 9-Cl, 8-CO2Me; R2 = H, 2-F, 2-Br, etc.] were synthesized via Pd-catalyzed domino reactions of acetylenic substrates involving intramol. trans-oxo/amino palladation onto the triple bond followed by nucleophilic addition of the intermediate to a tethered cyano/aldehyde. The scope of this reaction was extended through one step conversion of some of the products to 6H-dibenzo[c,h]chromen-6-ones and benzo[c]phenanthridines. Utilization of this methodol. led to a formal total synthesis of the natural product arnottin I.
Here is just a brief introduction to this compound(40400-13-3)Formula: C7H6BrI, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate