Obul, Mamateli; Wang, Xincheng; Zhao, Jiangyu; Li, Gen; Aisa, Haji Akber; Huang, Guozheng published the article 《Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus》. Keywords: influenza B virus rupestonic acid kidney cell; Artemisia rupestris; Benzylation; Influenza virus; Rupestonic acid.They researched the compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ).Safety of 1-(Bromomethyl)-2-iodobenzene. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:40400-13-3) here.
Influenza viruses are responsible for seasonal epidemics and occasional pandemics, which cause significant morbidity and mortality. Although several drugs (adamantanes and neuraminidase inhibitors) are available in the market, the worldwide spread of drug-resistant influenza strains poses an urgent need for novel antiviral drugs. Artemisia rupestris L. is a folk medicine used to treat cold. In this paper, we structurally modified rupestonic acid, a bioactive component of A. rupestris, to synthesize a series of 2-substituted rupestonic acid Me esters (3a-3o). Their structures were fully characterized by 1H NMR, 13C NMR, HRMS spectra. Among them, compounds 3b and 3c exhibited potent activities against influenza H1N1 with micromolar IC50 values and might serve as new lead compounds for the treatment of influenza.
Here is just a brief introduction to this compound(40400-13-3)Safety of 1-(Bromomethyl)-2-iodobenzene, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate